2 min to read
At 111SKIN, every formula begins with science. Behind the global success of our Repair Serum NAC Y2™ lies not a fleeting beauty trend, but a groundbreaking ingredient complex developed by a plastic and reconstructive surgeon for his patients’ most delicate skin needs.
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The Origins of NAC Y2™: A Surgeon’s Vision
When world-renowned surgeon Dr. Yannis Alexandrides set out to create a topical formula, it wasn’t with the goal of launching a skincare brand. His mission was simple: prepare and protect patients’ skin before and after surgery to achieve the best possible outcomes.
Many products available at the time were harsh, abrasive, and often unsuitable for sensitized skin. Drawing on decades of clinical experience and thousands of surgeries, Dr. Yannis turned to NAC (N-Acetyl Cysteine)—a trusted clinical compound used in medicine and even studied for protecting astronauts against oxidative stress in space.
To enhance its efficacy, he combined NAC with two powerful allies:
Vitamin C – A potent antioxidant that preserves the integrity of NAC while brightening and defending skin against free radical damage.
Escin – An anti-inflammatory molecule that improves oxygen delivery to the skin and helps reduce irritation.
These ingredients together create NAC Y 2™, a pioneering complex designed to support the body’s biggest organ, encouraging ongoing skin support, repair and rejuvenation while shielding it from daily stressors.
The NAC Y 2™ used in today’s 111SKIN products also utilise a breakthrough encapsulated delivery system, allowing the compound to penetrate deeper into the skin and release gradually for sustained repair.
What NAC Y2™ Does for Your Skin
NAC Y2™ is more than just another anti-ageing ingredient—it’s a clinically proven complex designed to repair, rejuvenate, and protect skin from daily stressors.
Independent clinical trials on Repair Serum NAC Y2™ have shown it to:
Reduce redness and irritation
Improve elasticity and firmness
Visibly reduce fine lines and wrinkles
- Protect against oxidative stress for long-term skin health
In fact, in just two weeks, 111SKIN’s hero product, Repair Serum NAC Y2™ has been proven to restore healthy skin, with 92% of users reporting a reduction in fine lines and an increase in radiance*.
The Repair Serum: The Product That Started It All
Launched in 2012, the Repair Serum NAC Y2™ was the first 111SKIN product to introduce this pioneering complex.
The Repair Serum NAC Y2™ was an evolution of the Healing Serum, which Dr. Yannis originally created for his clinical patients. The remarkable results experienced by Dr. Yannis’s patients through use of the Healing Serum quickly gained attention beyond the clinic. Through word of mouth, a buyer at Harrods discovered Dr Yannis’ creation, paving the way for the brand’s first launch into retail with the Repair Serum NAC Y2™. From there, 111SKIN has grown into a leading global luxury skincare brand, available at top retailers and spa partners worldwide and trusted by skincare experts, beauty insiders, and some of the world’s most recognisable faces.
More than a decade later, the Repair Serum NAC Y2™ continues to be the brand’s hero formula—earning multiple international beauty awards and a cult following among A-listers, dermatologists, aestheticians, and beauty editors alike.
Among its accolades:
Harper’s Bazaar Best Repair Serum – Anti-ageing Skincare Awards 2023
Modern Luxury Best Serum – Beauty Awards 2024
Real Skin, Real Results
The Repair Serum NAC Y2™ isn’t just clinically proven—it’s loved by real people around the world.
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“I’ve struggled with hormonal acne for years… this product has been one of the only things that has worked for my sensitive skin.”
Elisa | Verified customer
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“This serum is superb. After one week my skin is more hydrated, fine lines are reduced, and my complexion looks glowy—without irritation.”
Eileen M | Verified Customer
Why NAC Y2™ is the Future of Skincare
“The Repair Serum NAC Y2™ is more than skincare—it’s a clinical solution created to mirror the precision of surgery and the healing mechanisms of the body, refined with ingredients trusted in the most demanding environments, including space.”
With NAC Y2™ at its core, every drop of the Repair Serum delivers unparalleled skin resilience and radiance. And NAC Y2 is combined with a plethora of high-performance ingredients across the rest of the 111SKIN range to deliver outstanding visible results.
*Based on the results of a consumer trial of 28 participants after 4 weeks.
Words approved by: Dr Yannis Alexandrides
Dr. Yannis Alexandrides, founder of 111SKIN, is a renowned cosmetic surgeon and innovator in skincare. Informed by over 30 years of medical experience, his pioneering formulas merge science and luxury, delivering unparalleled results globally, redefining skincare standards.
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