4 min to read
From loss to renewal, discover the effects of rapid weight loss and the steps to restore strong, healthy skin.
Table of content
How does weight loss affect the skin?
Rapid weight loss, whether through diet, lifestyle changes, or medications like semaglutide (also known as Ozempic), can lead to loose, sagging skin and a hollow-looking appearance, sometimes referred to as “Ozempic skin”. Subcutaneous adipose tissue provides structural support for the dermis and when volume is lost quickly, skin may appear softer, sagging and visibly less toned.
Metabolic shifts associated with semaglutide therapy can affect the skin in several ways:
Reduced dermal support: Fibroblasts rely on tension from underlying fat to efficiently produce collagen and elastin; reduced tension can slow their activity.
Oxidative stress: Rapid changes may increase reactive oxygen species, accelerating collagen and elastin breakdown.
Altered ECM turnover: Imbalances between matrix metalloproteinases (MMPs) and their inhibitors may speed the degradation of structural proteins.
Barrier function changes: Lower hydration and reduced sebaceous activity can lead to dryness and subtle loss of radiance.
Together, these processes can result in laxity, fine lines, dryness and a dull complexion. While not medically harmful, these changes can affect appearance and skin quality, creating a need for targeted, specialised care.
What are the key skin challenges?
Supporting these skin concerns requires more than a surface-level treatment; it calls for a multi-layered approach which involves:
Restoring internal support lost through subcutaneous volume reduction.
Reinforcing collagen networks weakened by oxidative stress and reduced fibroblast activity.
Strengthening the skin barrier to lock in hydration and preserve resilience.
Emerging research shows that supporting fibroblast activity, boosting collagen production and strengthening antioxidant defences can help soften the visible effects of rapid weight loss. This highlights the value of a thoughtful, science-led approach to skincare.
111SKIN’s answer
A structured, science-backed skincare routine can help restore firmness, hydration and natural radiance. Layering advanced actives correctly not only provides instant results but also supports the skin’s long-term health.
MORNING ROUTINE
1. Cleanse
Gently remove impurities with the Enzyme Exfoliating Cleanser to support natural cell turnover without compromising the barrier.
3. Treat
Our Repair Serum NAC Y2™ accelerates repair, fortifies the barrier and stimulates collagen production.
The Eye Lift Gel NAC Y2™ targets the delicate eye area to enhance firmness and smoothness, helping counteract the subtle laxity seen in the orbital region following rapid weight loss.
4. Moisturise
Repair Day Cream NAC Y2™ hydrates, nourishes and fortifies the skin barrier for all-day resilience.
5. Protect
Repair Sunscreen SPF 50 shields against UV-induced collagen degradation and environmental stressors, critical for preserving structural proteins and preventing further laxity.
EVENING ROUTINE
1. Cleanse
Our Black Diamond Vitamin C Brightening Cleanser sweeps away impurities while boosting radiance and strengthening antioxidant defences. Vitamin C is a key co-factor in collagen production, supporting structural integrity, even as you sleep.
3. Treat
The Exosome Face Lift restores communication between fibroblasts and keratinocytes, stimulating collagen and elastin production for firmer, smoother and more refined skin.
Optional additions:
For enhanced nourishment, apply the Black Diamond Retinol Oil 2–3 times per week (avoiding exfoliation days) to further support collagen production and skin renewal. When used correctly, retinol enhances fibroblast activity and works in synergy with exosomes for even greater results.
Why Exosomes matter
Exosomes are tiny messengers naturally released by cells, carrying proteins, lipids and nucleic acids. Their role is to “reset” communication between fibroblasts and keratinocytes, helping to enhance tissue regeneration.
When it comes to “Ozempic skin,” exosomes can:
- Stimulate collagen and elastin to reinforce dermal structure and restore firmness.
- Soothe inflammation by reducing stress signals caused by sudden metabolic shifts.
- Strengthen the skin barrier, boosting hydration retention and overall resilience.
- Work hand in hand with retinol, preparing the skin to better tolerate and respond to active ingredients.
Supporting the skin from within
Topical care is only one piece of the puzzle. True skin health comes from pairing effective products with mindful lifestyle habits that amplify results.
Hydration: Staying well-hydrated helps preserve the skin’s barrier and elasticity.
Nutrition: Antioxidant-rich, protein-dense foods protect cells from oxidative stress and provide the building blocks for collagen and elastin.
Exercise: Gentle, consistent exercise boosts circulation and encourages the production of structural proteins.
Stress-management practices: Mindfulness, yoga or other relaxation techniques can also reduce the impact of oxidative and inflammatory stress on the skin.
Together, these habits create a strong foundation that allows targeted skincare to work more effectively, ensuring skin maintains elasticity, brightness and balance.
111SKIN’s takeaway
“Ozempic skin” reflects natural changes in dermal support, collagen networks and barrier function. With consistent, science-backed formulations, it is possible to gradually regain firmness, hydration and a natural, healthy radiance. Key actives, including exosomes, retinol, and NAC Y2™ work together to reinforce structural integrity, stimulate cellular renewal and support the skin’s natural repair processes.
This longevity-focused approach is all about strengthening the skin’s underlying architecture rather than providing temporary fixes. Over time, the skin becomes firmer, more resilient and visibly luminous, with a smoother texture and improved elasticity.
By combining targeted topical treatments with mindful lifestyle habits that support circulation, collagen production and antioxidant protection, the skin has a strong foundation to perform at its best, today and for years to come.
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Words approved by: Dr Yannis Alexandrides
Dr. Yannis Alexandrides, founder of 111SKIN, is a renowned cosmetic surgeon and innovator in skincare. Informed by over 30 years of medical experience, his pioneering formulas merge science and luxury, delivering unparalleled results globally, redefining skincare standards.
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