5 min to read
Introduction
Exosomes in skincare are one of the most powerful innovations in skin regeneration and anti-ageing treatments. These nano-sized messengers have the ability to stimulate collagen production, repair skin damage, and calm inflammation at a cellular level.
While originally used only in professional skin treatments, exosome therapy is now available in advanced at-home skincare protocols, making it easier than ever to achieve visible rejuvenation without downtime.
For a deep dive into what exosomes are and why they matter read part one of this journal series here.
Table of content
111SKIN’s Innovation: A Clinically Inspired Exosome Protocol with a visible lifting & tightening effect
Microneedling has long been recognised as a gold-standard treatment for boosting collagen and enhancing skin rejuvenation. When combined with exosomes in a clinical setting, it can significantly improve cellular uptake, skin texture, and healing time.
In-clinic microneedling
Dermapen and Potenza RF Microneedling are examples of in-clinic treatments using fine needles to create micro-injuries in the skin, allowing exosomes to penetrate deeply and accelerate collagen and elastin production. This approach delivers fast, targeted results, especially for scars, wrinkles, and pigmentation, but it involves downtime and professional supervision.
At-home exosome treatments
At-home treatments offer a gentler alternative. Results are more gradual but ideal for ongoing maintenance, sensitive skin, or those avoiding invasive procedures. Using delivery methods like microneedling tools such as derma rollers, they help enhance skin renewal and barrier repair without needles or recovery time.
111SKIN’s Exosome Face Lift harnesses an innovative delivery system in the form of microspicules which create tiny passages in the skin that allow the active ingredients to penetrate deep within the dermis.
111SKIN’s Innovation: A Clinically Inspired Exosome Protocol with visible a lifting & tightening effect
The 111SKIN Exosome Face Lift is a 4-week skin regeneration protocol designed by Dr Yannis Alexandrides to replicate the rejuvenating effects of professional exosome treatments offered at 111 Harley St. After four weeks of use, 97% agreed that skin appears visibly lifted**.
The protocol features Step 1: Exosome Shot Serum and Step 2: Exosome Overnight Mask, designed to work synergistically:
Step 1 delivers concentrated, signal-rich exosomes to stimulate cell communication and regeneration. Inspired by the powerful results achieved with exosomes in treatments at his clinic, 111 Harley St., Dr Yannis Alexandrides discovered an innovative delivery mechanism that has similar benefits to microneedling. Microspicules from a hydrolysed freshwater sponge are tiny, needle-like structures that effectively infuse exosomes into the skin, triggering a rejuvenating process. These microspicules help Exosomes reach 2x deeper into the skin*
- Step 2 acts as an occlusive layer, enhancing overnight absorption while calming redness and inflammation. The inclusion of Milk Thistle Extract in the formula helps to prevent the accumulation of senescent (so-called ‘zombie’) cells, which aids in restoring skin vitality whilst boosting collagen production.
This protocol supports:
Skin reset through stress reduction and improves skin's cellular communication, helping to boost collagen and elastin production
Targets damaged, senescent ("zombie") cells to encourage restoration and repair of skin overnight
Visible improvements in tone, wrinkles and firmness. 97% agreed that deep set lines and wrinkles appear reduced after 4 weeks**
"Regenerative medicine is rapidly reshaping the future of skincare, and exosomes are at the forefront of this shift. At my clinic, 111 Harley St, exosomes already play a key role in advanced treatments due to their remarkable ability to stimulate cell-to-cell communication - prompting the skin to repair, regenerate, and rejuvenate. It's incredibly exciting to bring a similar level of efficacy and results to bathroom cabinets at home."
Dr Yannis Alexandrides
How to Use the 111SKIN Exosome Face Lift
This protocol seamlessly integrates with your current nightly skincare routine to quickly deliver results and can be used nightly for 28 days. The protocol includes two steps designed to work together for fast-acting, optimal results inspired by our in-clinic treatments at 111 Harley St.
Step 1: Exosome Shot Serum
Apply 3–4 pumps to clean, dry skin on the face, neck, and décolletage.
Gently massage until absorbed.
Do not layer with other serums or actives.
Step 2: Exosome Overnight Mask
Apply 4 pumps evenly over the same areas.
Use as your final night-time step - do not apply moisturiser on top.
Leave on overnight and rinse off in the morning.
Key Guidelines
Use every night for 28 days, then stop. The protocol can be repeated up to 4 times a year.
Avoid retinoids and acids during the protocol. Reintroduce 24–48 hours after finishing.
After clinic treatments, wait 5–7 days before starting to allow the skin to heal.
Your go-to daily morning routine
After nourishing your skin overnight, this quick and simple morning ritual locks in the benefits, defends against daily stressors, and awakens a healthy, luminous glow - helping to preserve your skin’s youthful vitality all day long.
Differences Between At-Home Exosome Protocol vs. In-Clinic Microneedling
Best approach? Many users combine both using in-clinic microneedling for intensive treatments and at-home exosomes to support and prolong results between sessions. For optimal skin health, in-clinic microneedling sessions can be supported by the at-home protocol, either before to prime the skin, or after to accelerate recovery and maintain results. Just be sure to wait 5–7 days post-procedure before beginning at-home use, allowing the skin barrier to fully heal.
Can exosomes help with hyperpigmentation?
Yes – exosome serums can help fade post-inflammatory hyperpigmentation and brighten skin tone, especially when combined with effective delivery systems.
Can I use exosomes with retinoids or exfoliating acids?
Yes, but timing matters:
Mild retinoids: Resume use 24 hours after exosome application
Stronger retinoids: Wait 48 hours after exosome application
For acids (AHAs, BHAs, PHAs), it’s best to complete the full 28-day protocol first before reintroducing them, to avoid irritation and allow optimal skin regeneration.
Should I use a moisturiser with the Exosome Overnight Mask?
No. The Step 2: Exosome Overnight Mask is designed to be your final nighttime step. It forms a breathable occlusive layer that enhances absorption and overnight repair.
⚠️ Do not layer moisturiser or creams over the mask, as this may reduce its effectiveness.
Is the protocol safe for sensitive or compromised skin?
Generally, yes with precautions:
- Chronic inflammation (e.g. acne, rosacea): Suitable for mild to moderate cases; avoid if the skin is broken or actively inflamed
- Immunosuppressed individuals (e.g. diabetes, MS): Likely safe to apply topically, but we recommend consulting a physician prior to using exosomes
- Very sensitive skin: Patch test first or consult a dermatologist before starting
The Bottom Line: Professional-Level Skin Regeneration at Home
With exosome skincare, you can now achieve clinic-inspired anti-ageing results without leaving home. The 111SKIN Exosome Face Lift combines cutting-edge science with advanced delivery technology, giving your skin the tools it needs to repair, regenerate, and look visibly younger in just 28 days.
Discover the next generation of anti-ageing skincare. Shop the 111SKIN Exosome Face Lift now.
*Measuring the penetration of Lactosome 55 at 0h and 1h after application of the Exosome Shot Serum with and without Microspicules.
**Self-assessment of 30 participants after 4 weeks of product use.
Words approved by: Dr Yannis Alexandrides
Dr. Yannis Alexandrides, founder of 111SKIN, is a renowned cosmetic surgeon and innovator in skincare. Informed by over 30 years of medical experience, his pioneering formulas merge science and luxury, delivering unparalleled results globally, redefining skincare standards.
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