111SKIN's guide to pre and post procedure skincare

February 17, 2026 • 6 min to read

111SKIN was born from clinical insight rather than a cosmetic trend. In his 111 Harley St. practice, Dr Yannis Alexandrides recognised that optimal aesthetic results depend not only on the procedure itself, but also on how efficiently the skin recovers.

Guided by the reparative properties of N-Acetyl Cysteine (NAC), Dr Yannis developed NAC Y²™, 111SKIN’s proprietary reparative complex. This breakthrough formulation became the foundation of 111 Harley St’s first repair serum, designed to support sensitive skin after surgical procedures. Its results were so compelling that patients began requesting it for everyday use. From this demand, 111SKIN was born.

At a time when post-procedure skincare relied on abrasive, one-dimensional formulas, Dr Yannis set out to redefine repair. Using his advanced understanding of the skin’s three-dimensional repair process, his goal was for every 111SKIN formulation to actively support resilience and help regeneration without overwhelming the skin.

Today, 111SKIN remains grounded in that original philosophy. Our precisely engineered formulas prepare and support skin the skin before and after treatment, and preserve results over time while promoting long-term skin health and slowing visible signs of ageing.

Dr Yannis and his expert team at 111 Harley St. believe that the success of any aesthetic treatment begins before the appointment itself. Procedures such as injectables and lasers place the skin under controlled stress. When the skin is well-prepared (hydrated, balanced and structurally resilient), it responds more predictably, recovers efficiently and delivers refined results.

The team recommend that a daily routine should focus on strengthening the skin’s foundations, rather than stimulation or instant radiance. The focus should be on barrier support and optimal hydration – for maintaining overall skin health and getting it in its best condition before treatment. Calm, fortified skin is less prone to redness, uneven recovery and prolonged downtime.

In the final days before treatment, aggressive exfoliants and harsh actives should be put on pause to allow the skin to remain stable and receptive. Gentle cleansing, reparative serums, and daily broad-spectrum protection ensure the skin enters treatment in its most responsive state.

This considered approach supports smoother recovery and allows treatments to perform at their highest potential, laying the groundwork for results that are both visible and long-lasting.

The experts at 111 Harley St. recommend that recovery post-treatment should be intentional and minimal. Avoid excessive heat, intense exercise and direct sun exposure to allow the skin to fully recover. Gentle cleansing, consistent hydration and diligent sun protection form the foundation of recovery, calming redness and protecting sensitised skin.

Skincare should support natural repair: reparative serums restore the barrier, soothing masks reduce discomfort and active ingredients should be reintroduced gradually to refine tone and texture without disruption.

Aftercare is never one-size-fits-all. The needs of skin after injectables differ from those after laser resurfacing or chemical exfoliation. Below are our treatment-specific routines, developed by Milena Naydenov, Global Head of Aesthetics at 111 Harley St., to guide the skin seamlessly through recovery and beyond.

*The following routines are cosmetic skincare suggestions intended to support the appearance and comfort of skin. They are not medical aftercare instructions and should not replace advice provided by your treating practitioner. Products should only be used on intact skin and not be used on broken skin.

The longevity of Botox is intrinsically linked to skin quality. The eye area, both delicate and highly expressive, is particularly susceptible to movement, which can influence how long neuromodulator results are sustained.

111SKIN’s advanced eye treatments are designed to complement professional procedures, supporting smoother, firmer and younger-looking eyes through daily, cosmetic care. Our Eye Lift Gel NAC Y²™ and Celestial Black Diamond Contour Gel harness the power of high-concentration peptides, including Argireline and Matrixyl 3000, which helps improve elasticity and tone. NAC Y²™ protects against free radicals, while Caffeine de-puffs, brightens and revitalises tired eyes. Together, these ingredients lift, hydrate and firm, smoothing fine lines over time.